Volume 15 (2024)
Volume 14 (2023)
Volume 13 (2022)
Volume 12 (2021)
Volume 11 (2020)
Volume 10 (2019)
Volume 9 (2018)
Volume 8 (2017)
Volume 7 (2016)
Volume 6 (2015)
Volume 5 (2014)
Volume 4 (2013)
Volume 3 (2012)
Volume 2 (2011)
Volume 1 (2010)
The CB1 cannabinoid receptors involvement in anti-epileptic effect of safranal on penicillin-induced epileptiform activity in rats

Sina Tamaddonfard; Amir Erfanparast; Esmaeal Tamaddonfard; Farhad Soltanalinejad

Volume 15, Issue 1 , January 2024, , Pages 35-41

  Neuroprotective effects for natural products are supported by several studies. In this regard, safranal, a constitute of saffron, has the potential to exert beneficial effects in neurological disorders such as Parkinson's disease, epilepsy, stroke, multiple sclerosis and Alzheimer's disease. Here, we ...  Read More

Protective effects of propolis on ischemia-reperfusion injury in a rat testicular torsion and detorsion model

Emad Vakili-Sadeghi; Alireza Najafpour; Rahim Mohammadi

Volume 14, Issue 7 , July 2023, , Pages 389-395

  The torsion model of testis in a rat was adopted for evaluation of possible effects of propolis (Prop) on ischemia-reperfusion (IS/REP) injury. The healthy male Wistar rats (totally 24 animals) were randomized into four groups (n = 6) and animals experienced bilateral testicular torsions as follows: ...  Read More

Immunohistochemical determination of somatostatin release in gastric tissue of rats fed with a high-fat and cholesterol diet

Habibe Gündoğdu; Ebru Karadağ Sari

Volume 14, Issue 6 , June 2023, , Pages 309-315

  This study aimed to investigate the effects of a high-fat and cholesterol diet (HFCD) on rats gastric mucosa. In the study, a total of 16 (40-day-old Sprague Dawley) male rats were used and randomly divided into two groups (each consisted of eight rats). Rats in the control group had no implementations ...  Read More

Re: Protective effects of Chromolaena odorata extract on experimental benign prostatic hyperplasia in rats

Paula Alexandra Oliveira; Ana Faustino-Rocha; Elisabete Nascimento-Gonçalves

Volume 14, Issue 4 , April 2023, , Pages 177-178

  To the editor: We read the article entitled “Protective effects of Chromolaena odorata extract on experimental benign prostatic hyperplasia in rats” with great interest. This research aimed to evaluate the effects of hydro-methanol extract of Chromolaena odorata (HMECO) on testosterone propionate ...  Read More

Effects of ozone therapy on acidic corneal burns in rats

Seren Aydoğan; Hanifi Erol; Münevver Baran

Volume 14, Issue 4 , April 2023, , Pages 195-199

  In the present study the effect of ozone therapy on hydrofluoric acid (HFA) related eye burn was investigated in rats. A Total 20 healthy male Wistar albino rats (weighing 250 - 300 g with the age of 16 weeks) were used. They were divided into groups (experimental and control groups) of 10 rats being ...  Read More

Protective effects of Chromolaena odorata extract on experimental benign prostatic hyperplasia in rats

Remigius Ibe Onoja; Shodeinde Vincent Olumuyiwa Shoyinka; Jacinta Ngozi Omeke; Nnenna Tochi Emejuo; Stella Nkemdilim Ugwoke

Volume 14, Issue 2 , February 2023, , Pages 59-64

  Benign prostatic hyperplasia (BPH) is an age-related disease in dogs and man leading to prostate enlargement which impinges on the urethra causing urinary outflow obstruction. Due to the side effects of surgery and chemotherapy used for the treatment of this disease, attention is now focused on phytotherapeutics ...  Read More

Evaluation of di-n-butyl phthalate reproductive toxicity in pregnant rats and their offspring and assessment of vitamin E administration in reducing toxicity

Toktam Heidari; Rooz Ali Batavani; Hassan Malekinejad; Rahim Hobbenaghi

Volume 13, Issue 2 , June 2022, , Pages 201-208

  Phthalates are environmental contaminants mostly used as plasticizers and additives in different products. Having endocrine-disrupting properties, phthalates are known as potential reproductive toxicants. The present study was conducted to evaluate the reproductive toxicity of di-n-butyl phthalate (DBP) ...  Read More

Post-treatment with metformin improves random skin flap survival through promoting angiogenesis in rats

Mojtaba Karimipour; Gholam Hossein Farjah; Morteza Hassanzadeh; Masoumeh Zirak Javanmard

Volume 13, Issue 2 , June 2022, , Pages 233-239

  Skin flap necrosis has been remained as an unsolved problem in plastic and reconstructive surgeries. Here, we explored the effects of metformin post-treatment on random skin flap survival in rats. An 8.00 × 2.00 cm dorsal skin flap was created in 24 rats and they were then divided into three groups ...  Read More

Histomorphometrical evaluation of extensor digitorum longus muscle in sciatic nerve regeneration using tissue engineering in rats

Zahra Bakhtiary; Rasoul Shahrooz; Rahim Hobbenaghi; Saeed Azizi; Farhad Soltanalinejad; Ali Baradar Khoshfetrat

Volume 12, Issue 4 , December 2021, , Pages 451-457

  Skeletal muscle atrophy induced by denervation is one of the common disorders in traumatic nerve injuries. The aim of this study was the evaluation of histomorphometrical changes of extensor digitorum longus muscle after denervation and its regeneration by tissue engineering. Ninety adult male Wistar ...  Read More

Protective effects of Citrullus lanatus seed ethanol extract on aluminum ‎chloride-induced testosterone, testicular and hematological changes in an ‎experimental male rat model

Rita Ifeoma Odo; Chukwuka Nwocha Uchendu; Somtoo Ethelbert Okeke

Volume 12, Issue 1 , March 2021, , Pages 7-13

  The study was done to ascertain the protective potentials of ethanol seed extract of Citrullus lanatus on aluminum chloride-induced reproductive and hematological toxicities. Thirty mature male rats were used for the study. They were assigned into five groups (n=6). Group1was treated daily with aluminum ...  Read More

Protective effect of vitamin E on sperm quality and in vitro fertilizing potential and testosterone concentration in polyvinyl chloride treated Male rats

Abbas Sadeghi; Farah Farokhi; Ali Shalizar Jalali; Gholamreza Najafi

Volume 11, Issue 3 , September 2020, , Pages 257-263

  Polyvinyl chloride (PVC) has toxic effects through the induction of oxidative stress in the body and testicles. Vitamin E (Vit E) is a dietary compound that functions as an antioxidant scavenging toxic free radicals. The present study aimed to probe the protective effect of Vit E against PVC-induced ...  Read More

Silymarin protects the structure of kidney in the neonatal rats exposed to maternal cadmium toxicity: A stereological study

Gholamreza Hamidian; Shadmehr Mirdar; Pourya Raee; Kiyana Asghari; Maryam Jarrahi

Volume 11, Issue 2 , June 2020, , Pages 143-152

  The present study aimed to investigate the protective effect of silymarin on maternal cadmium toxicity complications in the kidney of neonatal rats. Forty adults Wistar female rats were selected and placed with male rats for copulation. The pregnant animals were randomly divided into five groups (n = ...  Read More

Antioxidant property of Plantago major leaf extracts reduces testicular torsion/detorsion-induced ischemia/reperfusion injury in rats

Masoumeh Moradi-Ozarlou; Sara Javanmardi; Hossein Tayefi Nasrabadi

Volume 11, Issue 1 , March 2020, , Pages 27-33

  The present study was aimed to determine the protective effects of Plantago major L (PM) leaf extracts on the testicular torsion/detorsion (T/D)-induced ischemia/reperfusion (I/R) injury in rats. Twenty-four mature male Sprague-Dawley rats, weighing 200-220 g, were selected. They were randomly divided ...  Read More

The effects of captopril on lipopolysaccharide-induced sickness behaviors in rats

Azam Abareshi; Akbar Anaeigoudari; Fatemeh Norouzi; Narges Marefati; Farimah Beheshti; Mohsen Saeedjalali; Mahmoud Hosseini

Volume 10, Issue 3 , September 2019, , Pages 199-205

  Neuro-immune mediators play an important role in the development of sickness behaviors. In the present study, the effect of captopril on sickness behaviors caused by lipopolysaccharide (LPS) was studied in the rats. The animals were randomized into the following groups: control, sham, 10 mg kg-1 captopril ...  Read More

Histomorphometric and immunohistochemical evaluation of angiogenesis in local ischemia by tissue engineering method in rat: Role of mast cells

Saeede Amani; Rasoul Shahrooz; Esmaeil Mortaz; Rahim Hobbenaghi; Rahim Mohammadi; Ali Baradar Khoshfetrat

Volume 10, Issue 1 , March 2019, , Pages 23-30

  The aim of this study was to find a proper method for improvement of ischemic condition in the rat hind limb and also to observe the efficacy of cell engraftment with alginate/gelatin three-dimensional scaffolds. Eighteen male Wistar rats weighing 200 to 250 g were randomly divided into three groups ...  Read More

Clinical Pathology
Effects of Urtica dioica hydro-alcoholic extract on blood serum glucose and lipid profiles of female Wistar rats with long-term estrogen deficiency

Abdolrasoul Namjou; Esfandiar Heidarian; Mahmoud Rafieian-kopaei

Volume 9, Issue 4 , December 2018, , Pages 349-355

  In this study, the effects of Urtica dioica hydro-alcoholic extract were investigated on the blood glucose and lipid profiles of female ovariectomized and non-ovariectomized rats. In total, 32 adult female rats were divided into four groups (eight each) including control and ovariectomy groups as well ...  Read More

Auto-transplantation of whole rat ovary in different transplantation sites

Somayeh Tavana; Mojtaba Rezazadeh Valojerdi; Hussein Eimani; Naeimeh Sadat Abtahi; Rouhollah Fathi

Volume 8, Issue 4 , December 2017, , Pages 275-280

  This study was carried out to assess the different ovarian transplantation sites after short-time autografting. Female rats were randomized into five groups, with six rats in each group, including control (intact), cervical subcutaneous transplanted (CST), back subcutaneous transplanted (BST), subfascial ...  Read More

Effect of chlorpyrifos on sperm characteristics and testicular tissue changes in adult male rats

Mojtaba Babazadeh; Gholamreza Najafi

Volume 8, Issue 4 , December 2017, , Pages 319-326

  Chlorpyrifos (CPF) is a broad spectrum organophosphate pesticide used for agricultural health purposes. Its principal mechanism of toxicity is the inhibition of acetylcholinesterase. The purpose of present study was to investigate the effects of CPF on testicular tissue and sperm parameters in male rats. ...  Read More

Effects of Guajol® ointment synthesized from medicinal smoke condensate of jennet feces on burn wound healing on Wistar rat

Farhad Safarpoor Dehkordi; Farhang Tirgir; Yousef Valizadeh

Volume 8, Issue 3 , September 2017, , Pages 215-221

  Application of smoke condensate derived from an indirect heating of jennet feces (Sargin) had been recommended by Iranian ancient scientists as a therapeutic agent. The present study was done to evaluate the healing effects of Guajol® ointment on burn wound in rat. The Guajol® ointment was prepared ...  Read More

Ameliorative effects of Achillea millefolium inflorescences alcoholic extract on nicotine-induced reproductive toxicity in male rat: Apoptotic and biochemical evidences

Ameneh Hasanzadeh Khosh; Shapour Hasanzadeh; Ali Shalizar Jalali

Volume 8, Issue 2 , June 2017, , Pages 97-104

  Nicotine (NIC) adversely influences male reproductive system. Achillea millefolium (Achm) as a medicinal plant is highly regarded for its antioxidant and anti-inflammatory properties. The present study was conducted to assess whether Achminflorescences alcoholic extract could serve as a protective agent ...  Read More

Curcumin-loaded poly lactic-co-glycolic acid nanoparticles effects on mono-iodoacetate -induced osteoarthritis in rats

Firoozeh Niazvand; Layasadat Khorsandi; Mohammadreza Abbaspour; Mahmoud Orazizadeh; Negar Varaa; Mahtab Maghzi; Kheironesa Ahmadi

Volume 8, Issue 2 , June 2017, , Pages 155-161

  Curcumin has been found to be very efficacious against many different types of diseases. However, the major disadvantage associated with the use of curcumin is its low systemic bioavailability. In the present study the protective effects of curcumin-loaded poly lactic-co-glycolic acid nanoparticles (nanocurcumin) ...  Read More

Role of μ-opioid receptor in parafascicular nucleus of thalamus on morphine-induced antinociception in a rat model of acute trigeminal pain

Esmaeal Tamaddonfard; Amir Erfanparast

Volume 8, Issue 1 , March 2017, , Pages 29-34

  The parafascicular nucleus (PFN) of thalamus, as a supraspinal structure, has an important role in processing of nociceptive information. In addition, μ-opioid receptor contributes to supraspinal modulation of nociception. In the present study, the effects of microinjection of naloxone (a non-specific ...  Read More

Clinical Pathology
Effect of soy milk on circulating 17- β estradiol, number of neurons in cerebral cortex and hippocampus and determination of their ratio in neonatal ovariectomized rats

Behrokh Marzban Abbasabadi; Mina Tadjalli

Volume 7, Issue 4 , December 2016, , Pages 347-351

  This study was conducted to evaluate the effect of soy milk on serum 17- β estradiol level and number of neurons in cerebral cortex and hippocampus as well as determination of the ratio of neurons in cortical and hippocampal regions in neonatal ovariectomized rats. Thirty female rats (one day old) ...  Read More

Anti-spermatogenic activities of Taraxacum officinale whole plant and leaves aqueous extracts

Lubna Hamid Tahtamouni; Rema Ahmad Al-Khateeb; Reem Nasser Abdellatif; Zainab Ali Al-Mazaydeh; Salem Refaat Yasin; Samer Al-Gharabli; Ali Zuhair Elkarmi

Volume 7, Issue 2 , June 2016, , Pages 89-97

  Taraxacum officinale has been used in Jordan folk medicine to treat male infertility. A recent study has proved a contradictory effect of the whole plant aqueous extract. The aim of the current study was to determine if the leaves of T. officinale have similar anti-fertility activities, and whether this ...  Read More

Protective effect of quercetin on skeletal and neural tube teratogenicity induced by cyclophosphamide in rat fetuses

Mahmood Khaksary Mahabady; Mohammad Reza Gholami; Hossein Najafzadeh Varzi; Abolfazl Zende del; Mona Doostizadeh

Volume 7, Issue 2 , June 2016, , Pages 133-138

  Cyclophosphamide (CP) is a drug commonly used to treat neoplastic disease and some autoimmune diseases. It is also a well-known and well-studied teratogen causing a variety of birth defects in fetuses of pregnant women treated with the drug. There are many reports that show the adverse effects of CP ...  Read More